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The "Helicobacter Foundation" was founded by Prof. Barry J. Marshall in early 1994, and is cipro dedicated to providing you with the latest information about Helicobacter pylori, its diagnosis, treatment and clinical perspectives.

The story of why it took 100 years to discover Helicobacter is described in these pages.

You should discuss various treatment options, their risks and benefits, with your own doctor. Be aware that treatment of H. pylori is not always recommended by all experts on H. pylori, or in all patients with H. pylori.

Each patient is an individual and decisions must be made in concert with his or her own medical practitioner on a case-by-case basis. The Helicobacter Foundation makes a good faith attempt to ensure that information provided is accurate and up-to date. Most of the information has been published or presented at national and international scientific meetings.

The Helicobacter Foundation makes no guarantees about the accuracy of this information which is given free of charge to whomever requests it. Please help support this website by donating via the button below.

 

 

Information for Prof Marshall's patients: Side-effects of Drugs used in Rescue Therapies

When patients' Helicobacter strains are resistant to the standard treatment, unusual combinations of antibiotics must be used for eradication.

Although used worldwide, some of these are not registered for use in Australia by the Therapeutic Goods Administration TGA. These are bismuth, furazolidone, tetracycline and metronidazole.

Prof Barry Marshall is authorized to prescribe these medications for the eradication of antibiotic resistant H. pylori under the TGA's Special Access Scheme.

His patients need to be aware that

¤ these drugs have not been evaluated for safety, quality or efficacy by the TGA

¤ there are some risks and side-effects,

¤ there is a possibility of unknown risks and late side-effects.

With these and other drugs we find that many patients do not suffer any side-effects, a few suffer mild side-effects and rarely side-effects can be severe.

For more information about the side effects of these and other drugs prescribed by Prof Marshall please click here.

If you experience a severe side-effect please gain the advice of your GP or go straight to Emergency.

 

Medication

Use

Adverse Side Effects

Amoxicillin

Antibiotic; as penicillin; bacterial infections

Hypersensitivity; infection; severe skin reactlons/rash

Ciprofloxacin

Antibacterial; antibiotic; infections

Agitation; anorexia; depression; dizziness; headache; impaired alterness; superinfection; tendon rupture

Clarithromycin

Antibiotic; Infections

Altered taste; dizziness; fever; headache; severe skin reactions/rash; superinfection

DeNol

Antiulcer

Black bowel motions; constipation; diarrhoea; nausea; vomiting

Furazolidone

Antibacterial; antibiotic; infections

Diarrhoea; discoloured urine; headache; nausea; stomach or abdominal pain; vomiting

Metronidazole

Antibacterial; antibiotic; infections (anaerobic)

Dark urine; dry mouth; hypersensitivity; metallic, unpleasant taste; nasal congestion; superinfection; visual disorder

Rabeprazole

Antiulcer; hyperacidity; reflux

Back or chest pain; cough; dizziness; dry mouth; flu-like syndrome; headache; hypersensitivity; infection; insomnia

Rifabutin

Bactericidal antibiotic; often for tuberculosis

Discoloured urine; GI symptoms; rash

Tetracycline

Antibiotic; bacterial infections

Anorexia; hypersensitivity; hypertension; rash; skin photosensitivity; superinfection; tooth discolouration

 

Class

Generic Name

Brand Name

Common Uses

Possible Side Effects

Mechanism giardia medication cipro of action

Macrolides

Azithromycin

Sumamed

Streptococcal infections, syphilis, upper respiratory tract infections, lower respiratory tract infections, mycoplasmal infections, Lyme disease.

Nausea, vomiting and diarrhea (especially at higher doses).

Inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosomal, thereby inhibiting translocation of peptidyl tRNA.

Xithrone

Zithromax

Prolonged QT interval (especially erythromycin).

Clarithromycin

Biaxin

Klacid

Jaundice.

Erythromycin

Erythocin

Erythroped

Roxithromycin

Roximycin

Nitrofurans/Nitroimidazoles

Furazolidone

Furoxone

Bacterial or protozoal diarrhea or enteritis

Diarrhea, discolored urine, headache, nausea, stomach or abdominal pain, vomiting.

Metronidazole

Flagyl

Infections caused by anaerobic bacteria; also amoebiasis, trichomoniasis, Giardiasis.

Discolored urine, headache, metallic taste, nausea; alcohol is contraindicated.

Produces toxic free radicals which disrupt DNA and proteins. This non-specific mechanism is responsible for its activity against a variety of bacteria, amoebae, and protozoa.

Tinidazole

Fasigyn

Anti-parasitic drug used against protozoan infections. Infections from amoebae, giardia and trichomonas. Bacterial infections.

Tinidazole has similar side effects as Metronidazole. Upset stomach, bitter taste and itchiness. Other side effects which occur are headache, physical fatigue, and dizziness.

Simplotan

Sporinex

Tindamax

Penicillins

Amoxicillin

Amoxil

Wide range of infections; penicillin used for streptococcal infections, syphilis, and Lyme disease.

Gastrointestinal upset and diarrhea. Allergy with serious anaphylactic reactions. Brain and kidney damage (rare).

Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls.

Novamox

Quinolones

Ciprofloxacin

Cipro

Urinary tract infections, bacterial prostatitis, community-acquired pneumonia, bacterial diarrhea, mycoplasmal infections, gonorrhea.

Nausea (rare), irreversible damage to central nervous system (uncommon), tendinosis (rare).

Inhibit the bacterial DNA gyrase or the topoisomerase IV enzyme, thereby inhibiting DNA replication and transcription.

Ciprobay

Ciproxin

Moxifloxacin

Avelox

Tetracyclines

Doxycycline

Vibramycin

Syphilis, chlamydial infections, Lyme disease, mycoplasmal infections, acne rickettsial infections, malaria Note: Malaria is caused by protist and not a bacterium.

Gastrointestinal upset.

Inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex. They do so mainly by binding to the 30S ribosomal subunit in the mRNA translation complex.

Sensitivity to sunlight.

Potential toxicity to mother and fetus during pregnancy.

Enamel hypoplasia (staining of teeth; potentially permanent).

Tetracycline

Achromycin V


Source: http://www.helico.com/welcome.html


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